Vaccines

Prophylactic Vaccines

Therapeutic Approach:

Develop VacciDEEP declensional peptides for inducing protective immunity to hypervariable infectious disease pathogens such as H5N1 influenza, H1N1 influenza, and Dengue Fever.

Therapeutic Vaccines

Therapeutic Approach:

Develop VacciDEEP declensional peptides as immunotherapy for solid tumor oncology indications such as melanoma, head and neck, glioma, pancreatic, ovarian and non-small cell lung cancers.

H5N1 Avian Flu:

VacciDEEP declensional peptides encompass major polymorphism on head region of hemagluttinin envelope protein

  • DEEP thrives on antigenic complexity
  • Antibody-mediated protection
  • Incorporate most amino acid substitutions in HA receptor region
  • Anticipate future antigenic drifts
  • Built-in T-cell determinant(s)
  • MHC promiscuous
  • Drives immune response away from
    evolution-imposed immunodominance
  • No need for carrier proteins
  • Antibody-mediated viral clearance should facilitate “herd immunity”
Significant Memory Response

A single dose of VacciDEEP declensional peptide induces a long-term T-cell memory response in healthy male volunteers without the use of adjuvant

HA1