DEEP™ Technology

Technology

DEEP Technology is the Directed Expansion of Epitope Permutations through the manufacture of Amino Acid Copolymers with Antigenic Specificity, i.e., Declensional Peptides: Mixture of 40-80 amino acid-long peptides manufactured in a single solid phase peptide synthesis, incorporating more than one amino acid at a given position.

Directed Expansion of Epitope Permutations (DEEP):

  • Design and manufacture of determinant-specific amino acid copolymers
  • Intrinsic immunogenicity
  • Th2/Th3-prone immunity through large percentage of alanine
  • Broad and specific response against multiple variants
  • Combined B- and T-cell determinants
  • HLA promiscuity
  • Juxtaposition of peptidic regions and incorporation of modified amino acids, e.g., phosphorylation, nitration, glycosylation

ModuloDEEP™

Declensional peptides for the treatment of neurodegenerative and autoimmune disorders

VacciDEEP™

Declensional peptides as prophylactic or therapeutic vaccines for infectious disease or cancer

AntiDEEP™

Declensional peptides as ligands for antibody discovery

Route SC ID ID
Adjuvant No Yes Yes
Dose mg μg μg-mg
Dosing regimen Chronic weekly 1-3 monthly 1-3 bi-weekly
Alanine content High Low Low